There is a gene named after Sonic the Hedgehog. It plays an important role in embryonic development, and if mutated, can cause holoprosencephaly (when the brain does not separate into two hemispheres), which in turn can lead to cyclopia (cyclopsism).

It was named for the videogame character not for its ability to jump and catch golden rings, but because it was the early 1990s and the other two “hedgehog” genes had already been discovered.

Nature (source)